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tecovirimat will boost the amount or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Monitor for adverse consequences if coadministered with delicate substrates of these enzymes.diazepam increases amounts of lomitapide by influencing hepatic/intestinal en